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Little is known about cancer therapy-related cardiac dysfunction occuring in children treated by anticancer drugs for malignancies. Here the investigators use VigiBase (http://www.vigiaccess.org/), the World Health Organization (WHO) database of individual safety case reports, to identify and describe cases of cancer therapy-related cardiac dysfunction associated with anticancer drugs.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| use of anticancer drugs in monotherapy or in combination therapy | Drug | Cases of cancer therapy-related cardiac dysfunction associated with anticancer drugs will be identify and describe |
| Measure | Description | Time Frame |
|---|---|---|
| cancer therapy-related cardiac dysfunction associated with anticancer drugs | identification and description of cases of cancer therapy-related cardiac dysfunction associated with anticancer drugs in the World Health Organization (WHO) database of individual safety case reports (vigibase) | from inception to the April 31, 2024 |
| Measure | Description | Time Frame |
|---|---|---|
| Association between cancer therapy-related cardiac dysfunction and anticancer drug exposure in the World Health Organization (WHO) database of individual safety case reports (vigibase) | Disproportionnality analyses in Vigibase (IC025 and/or ROR) perfomed on cases reported in the World Health Organization (WHO) database of individual safety case reports (vigibase) | from inception to the April 31, 2024 |
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Inclusion Criteria:
Exclusion Criteria:
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Cases reported in the World Health Organization (WHO) database of individual safety case reports (vigibase) related to children and reported, or not, cancer therapy-related cardiac dysfunction
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joachim Alexandre, MD, PhD | Contact | +330231064770 | alexandre-j@chu-caen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Joachim Alexandre, MD, PhD | Caen Normandy University Hospital, France | Principal Investigator |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D002318 | Cardiovascular Diseases |
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| Description of the malignancies for which the incriminated drugs have been prescribed | Cases reported in the World Health Organization (WHO) database of individual safety case reports (vigibase) | from inception to the April 31, 2024 |