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| Name | Class |
|---|---|
| Centre Hospitalier Régional de la Citadelle | OTHER |
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The goal of this prospective interventional study is to improve the detection of subclinical chronic Cancer Therapy-Related Cardiovascular Toxicity (CTRCT) and evaluate the added value of advanced cardioechography, ergospirometry, and specific biomarkers in pediatric cancer survivors (aged 2 to 25) who received potentially cardiotoxic treatments (chemotherapy/thoracic radiotherapy). The main questions it aims to answer are:
At time of follow-up, if they agree, participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pediatric Cancer Survivors in CHU Liege | Experimental | Patients aged 2 to 25 years followed at CHU de Liège, who have received potentially cardiotoxic treatment (chemotherapy and/or thoracic radiotherapy) for pediatric cancer or bone marrow transplantation since January 1st, 2016 and are in remission for at least 1 year. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ergospirometry | Diagnostic Test | Completion of validated, age-appropriate quality of life scales and physical activity assessment forms. Patients over 8 years of age will perform a standardized cardiopulmonary exercise test (CPET / ergospirometry) on a treadmill. Seven-day continuous monitoring using a wearable accelerometer. Collection of a 10 mL blood sample (one EDTA tube and one serum-clotting tube), to be centrifuged and stored at -80°C in the CHU de Liège "BHUL" biobank. |
| Measure | Description | Time Frame |
|---|---|---|
| EKG anomaly | Presence of arrhythmia, prolonged QTc interval, or conduction disorders. | At inclusion (single study visit) |
| Echocardiography anomaly: systolic dysfunction | Systolic dysfunction: LVEF < 55% or a relative decrease of >15%. | At inclusion (single study visit) |
| Echocardiography anomaly: diastolic dysfunction | Based on standardized pediatric values :
| At inclusion (single study visit) |
| Echocardiography anomaly: Significant alteration in myocardial deformation | GLS decrease > 15% | At inclusion (single study visit) |
| Echocardiography anomaly: myocardial work indices | abnormal Myocardial Work indices | At inclusion (single study visit) |
| Echocardiography anomaly: valvular disease or heart inflammation | Structural/Inflammatory damage: Significant valvular disease, or signs of acute/chronic pericarditis and myocarditis. | At inclusion (single study visit) |
| Cardiopulmonary Exercise Testing (CPET): Impaired functional capacity | defined as peak VO2 < 85% or maximal workload < 85% of predicted theoretical values. | At inclusion (single study visit) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caroline E M Jacquemart | Contact | +32 4 3218451 | caroline.jacquemart@chuliege.be | |
| Catherine Sondag | Contact | etudes.pediatrie@chuliege.be |
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|
|
| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D011832 | Radiation Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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