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Based on the progress of cataract surgery, intraocular lens development, vitreoretinal surgery and anesthesia technology in recent years, the purpose of this study is to develop a new type of more accurate and minimally invasive combined surgery for cataract and fundus diseases, and to evaluate the advantages and value of the surgery as well as related complications, so as to minimize the surgical trauma and obtain faster visual function recovery and better patient comfort. To provide new solutions for the growing demand of eye health care.
To evaluate the efficacy and complications of a new type of minimally invasive femtosecond laser assisted-cataract surgery (FLACS) combined with pars plana vitrectomy (PPV) with two-step anesthesia in the treatment of various common fundus diseases such as rhegmatogenous retinal detachment (RRD), epiretinal membrane (ERM), macular hole (MH), and vitreous opacity, complicated with cataract. It is mainly aimed at the following kinds of common fundus diseases with cataract performing PPV and cataract removal combined with monofocal or premium intraocular lens (IOL) implantation： RRD complicated with cataract: FLACS +PPV + IOL+air; ERM complicated with cataract: FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex; MH complicated with cataract: FLACS + PPV+ IOL + internal limiting membrane peeling + air; Vitreous opacity with cataract: FLACS + PPV+ IOL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RRD group | Experimental | to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of rhegmatogenous retinal detachment complicated with cataract. |
|
| ERM group | Experimental | to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of epiretinal membrane complicated with cataract. |
|
| MH group | Experimental | to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of macular hole complicated with cataract. |
|
| Vitreous cloudy group | Experimental | to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of vitreous opacity complicated with cataract. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FLACS +PPV+IOL + air | Procedure | The procedures are combined the FLACS +PPV+IOL + air. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| visual acuity | final best-corrected visual acuity | Change from baseline best-corrected visual acuity at 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| complications | complications occurred during surgery or post-surgery | through study completion, an average of 6 months. |
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Inclusion Criteria: clinical diagnosis of following disease
Exclusion Criteria: patients with history of following condition
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jiasong Yang | Contact | +8619916531690 | cammel@qq.com | |
| Wensheng Li | Contact | +8613761975020 | drlws@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Wensheng Li | Aier Ophthalmology School of Central South University; Shanghai Aier Eye Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiasong Yang | Recruiting | Shanghai | 200000 | China |
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| FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex |
| Procedure |
The procedures are combined the FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex. |
|
| FLACS + PPV+IOL + internal limiting membrane peeling + air | Procedure | The procedures are combined the FLACS + PPV+IOL + internal limiting membrane peeling + air. |
|
| FLACS + PPV+IOL | Procedure | The procedures are combined the FLACS + PPV+IOL. |
|
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D019773 | Epiretinal Membrane |
| D002386 | Cataract |
| D014823 | Vitreous Hemorrhage |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D007905 | Lens Diseases |
| D005130 | Eye Hemorrhage |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000388 | Air |
| D002123 | Calcium Dobesilate |
| ID | Term |
|---|---|
| D001272 | Atmosphere |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |
| D001557 | Benzenesulfonates |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D001190 | Arylsulfonates |
| D017739 | Arylsulfonic Acids |
| D013451 | Sulfonic Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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