Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions

Clinical and Topographic Evaluation of the Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions (a Randomized Controlled Clinical Trial and In-vitro Study)

The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.

Inclusion Criteria:

• Patients who at least have 1 white spot lesion.
• No systemic diseases or taking any medication affecting salivary flow.
• Patients with good oral hygiene measures.
• Patients with moderate caries risk assessment.
• Post orthodontic WSLs with International Caries Detection and Assessment System (ICDAS II) scoring criteria (1-2).

Exclusion Criteria:

• Participant in another trial.
• Developmental non carious lesion (enamel hypoplasia and dental fluorosis).
• Presence of abnormal oral disease, or medically compromised patients.
• Participants who had evidence of reduced salivary flow or significant tooth wear.
• Allergy to milk products or other drug allergies.