The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.

Inclusion Criteria:

• Patients who at least have 1 white spot lesion.
• No systemic diseases or taking any medication affecting salivary flow.
• Patients with good oral hygiene measures.
• Patients with moderate caries risk assessment.
• Post orthodontic WSLs with International Caries Detection and Assessment System (ICDAS II) scoring criteria (1-2).

Exclusion Criteria:

• Participant in another trial.
• Developmental non carious lesion (enamel hypoplasia and dental fluorosis).
• Presence of abnormal oral disease, or medically compromised patients.
• Participants who had evidence of reduced salivary flow or significant tooth wear.
• Allergy to milk products or other drug allergies.