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Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group DD1 | Experimental | tACS + visuo-attentional training |
|
| Group DD2 | Active Comparator | Sham (placebo) tACS + visuo-attentional training |
|
| Group DD3 | Active Comparator | Sham (placebo) tACS + phonics training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Parietal tACS combined with visuo-attentional training | Device | Parietal tACS combined with visuo-attentional training |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reading score | Text, word and pseudowords reading score | Pre-training, 1-7 days post-training, follow-up at 1 and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luca Ronconi | Milan | Italy | 20132 | Italy |
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| ID | Term |
|---|---|
| D004410 | Dyslexia |
| ID | Term |
|---|---|
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| Sham (placebo) tACS combined with visuo-attentional training | Device | Sham (placebo) tACS combined with visuo-attentional training |
|
| Sham (placebo) tACS combined with phonics training | Device | Sham (placebo) tACS combined with phonics training |
|
| D009422 | Nervous System Diseases |
| D000067559 | Specific Learning Disorder |
| D007859 | Learning Disabilities |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |