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| ID | Type | Description | Link |
|---|---|---|---|
| 707246 | Other Grant/Funding Number | Canadian Cancer Society | |
| POC-181042 | Other Grant/Funding Number | Canadian Institutes of Health Research |
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| Name | Class |
|---|---|
| Canadian Cancer Society (CCS) | OTHER |
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
| McMaster University | OTHER |
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The purpose of this study is to determine the efficacy of performing "exercise snacks" (short movement breaks throughout the day) on various measures of cardiometabolic health.
After being informed about the study and potential risks, all eligible participants who have provided consent will undergo a baseline visit to assess pre-intervention basic anthropometrics, cardiorespiratory fitness, and provide a blood sample. Participants will then be randomized in a 1:1 ratio to one of two groups: 1) Mobility movement breaks (stretching or range of motion exercises); or 2) Cardiovascular movement breaks (designed to raise heart rate). Both groups will be encouraged to perform 3-4 daily movement breaks on at least 3 days of the week with support from an online platform and app that provides video instructions and reminders to complete the movement breaks. After 12 weeks, participants will be asked to return to the lab for the same testing performed at baseline.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cardiovascular Movement Breaks | Experimental | Participants will perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm will be designed to increase heart rate. |
|
| Mobility Movement Breaks | Active Comparator | Participants will perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm are not designed to increase heart rate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Movement Breaks | Behavioral | Participants will be asked to perform 30-60 second movement breaks 3-4 times per day on at least 3 days per week. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline in Cardiorespiratory Fitness at 12 Weeks | Cardiorespiratory fitness will be assessed as the highest 30-s average from a laboratory-based graded VO2peak test on a cycle ergometer. | Baseline and Week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline in Plasma Insulin | A fasted venous blood sample will be obtained and insulin measured by commercial assay. | Baseline and 12 weeks |
| Change From Baseline in Plasma Glucose | A fasted venous blood sample will be obtained and glucose measured by biochemical assay. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jonathan Little | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia | Kelowna | British Columbia | V1V 1V7 | Canada | ||
| McMaster University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40772837 | Derived | Babir FJ, Islam H, McCreary S, Vaz E, Falkenhain K, Cranston K, Jung M, Singer J, Sandilands R, Marcotte-Chenard A, Stamatakis E, Richards DL, Gibala MJ, Little JP. Technology-Enabled Exercise "Snacks" Are Feasible to Perform in a Real-World Setting: A Randomized Controlled Trial. Scand J Med Sci Sports. 2025 Aug;35(8):e70117. doi: 10.1111/sms.70117. |
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77 participants were included in the intention-to-treat analyses
Online recruitment primarily through use of third-party service.
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| ID | Title | Description |
|---|---|---|
| FG000 | Cardiovascular Movement Breaks | Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate. |
| FG001 | Mobility Movement Breaks | Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Cardiovascular Movement Breaks | Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate. |
| BG001 | Mobility Movement Breaks |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Age in years |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change From Baseline in Cardiorespiratory Fitness at 12 Weeks | Cardiorespiratory fitness will be assessed as the highest 30-s average from a laboratory-based graded VO2peak test on a cycle ergometer. | Intention-to-treat | Posted | Mean | 95% Confidence Interval | ml/kg/min | Baseline and Week 12 |
|
12 weeks
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Cardiovascular Movement Breaks | Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Jonathan Little | University of British Columbia | 250-807-9876 | jonathan.little@ubc.ca |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Apr 11, 2022 | Feb 6, 2025 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Feb 26, 2024 | Feb 6, 2025 | SAP_001.pdf |
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| ID | Term |
|---|---|
| D057185 | Sedentary Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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Participants will be randomized (1:1 allocation ratio) into Mobility or Cardiovascular movement break groups for 12-weeks. Both groups will perform 3-4 movement breaks on at least 3 days of the week.
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Outcome assessors will not be aware of group allocation and statistics performed on data with group identity blinded.
|
| Baseline and 12 weeks |
| Change From Baseline in Insulin Resistance | A fasted venous blood sample will be obtained and insulin resistance estimated by homeostasis model assessment (HOMA) score | Baseline and 12 weeks |
| Change From Baseline in Inflammatory Cytokines | A fasted venous blood sample will be obtained and inflammatory cytokines measured by multiplex assay | Baseline and 12 weeks |
| Change From Baseline in Body Mass | Body mass will be measured by weigh scale | Baseline and 12 weeks |
| Change From Baseline in Waist Circumference | Waist circumference (in centimetres) will be measured using a measurement tape. | Baseline and 12 weeks |
| Device-Measured Adherence to Movement Breaks | Participants will wear accelerometers to assess adherence near the beginning and the end of the intervention. | Week 2 and week 11 |
| Self-Reported Adherence to Movement Breaks | Participants will be sent weekly surveys asking them to recall the total number of movement breaks performed that week. | Once per week for 12 weeks |
| Movement Break Enjoyment Assessed by the Exercise Enjoyment Scale (EES) | The EES is a validated, single-item 7-point scale to assess exercise enjoyment. Possible scores range from 1 (not at all) to 7 (extremely). | Immediately following each movement break for entire 12-week intervention |
| Rating of Perceived Exertion (RPE) Following Movement Breaks | A 10 point RPE scale will be used to assess perceived exertion ranging from 0 (rest) to 10 (maximal). | Immediately following each movement break for entire 12-week intervention |
| Hamilton |
| Ontario |
| Canada |
Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate. |
| BG002 | Total | Total of all reporting groups |
| Standard Deviation |
| Years |
|
| Sex: Female, Male | Biological sex assigned at birth | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| VO2peak | Relative VO2peak from maximal cycle ergometer test | Mean | Standard Deviation | ml/kg/min |
|
|
|
| Secondary | Change From Baseline in Plasma Insulin | A fasted venous blood sample will be obtained and insulin measured by commercial assay. | Intention-to-treat | Posted | Mean | 95% Confidence Interval | percent change | Baseline and 12 weeks |
|
|
|
| Secondary | Change From Baseline in Plasma Glucose | A fasted venous blood sample will be obtained and glucose measured by biochemical assay. | Not Posted | Baseline and 12 weeks | Participants |
| Secondary | Change From Baseline in Insulin Resistance | A fasted venous blood sample will be obtained and insulin resistance estimated by homeostasis model assessment (HOMA) score | Not Posted | Baseline and 12 weeks | Participants |
| Secondary | Change From Baseline in Inflammatory Cytokines | A fasted venous blood sample will be obtained and inflammatory cytokines measured by multiplex assay | Not Posted | Baseline and 12 weeks | Participants |
| Secondary | Change From Baseline in Body Mass | Body mass will be measured by weigh scale | Not Posted | Baseline and 12 weeks | Participants |
| Secondary | Change From Baseline in Waist Circumference | Waist circumference (in centimetres) will be measured using a measurement tape. | Not Posted | Baseline and 12 weeks | Participants |
| Secondary | Device-Measured Adherence to Movement Breaks | Participants will wear accelerometers to assess adherence near the beginning and the end of the intervention. | Not Posted | Week 2 and week 11 | Participants |
| Secondary | Self-Reported Adherence to Movement Breaks | Participants will be sent weekly surveys asking them to recall the total number of movement breaks performed that week. | Not Posted | Once per week for 12 weeks | Participants |
| Secondary | Movement Break Enjoyment Assessed by the Exercise Enjoyment Scale (EES) | The EES is a validated, single-item 7-point scale to assess exercise enjoyment. Possible scores range from 1 (not at all) to 7 (extremely). | Not Posted | Immediately following each movement break for entire 12-week intervention | Participants |
| Secondary | Rating of Perceived Exertion (RPE) Following Movement Breaks | A 10 point RPE scale will be used to assess perceived exertion ranging from 0 (rest) to 10 (maximal). | Not Posted | Immediately following each movement break for entire 12-week intervention | Participants |
| 0 |
| 38 |
| 0 |
| 38 |
| 0 |
| 38 |
| EG001 | Mobility Movement Breaks | Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate. | 0 | 39 | 0 | 39 | 0 | 39 |
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