In this randomized controlled study, preventive intervention of aspirin combined with probiotics or aspirin combined with placebo would given to PE (pre-eclampsia) high-risk population with gut microbiota dysbiosis during their pregnancy, and finally assess the efficacy and safety of aspirin combined with probiotics to prevent PE.

Inclusion Criteria:

• PE high-risk population aged 18-50 years with gut microbiota dysbiosis
• No severe cardiopulmonary diseases
• No severe hepatic and renal insufficiency
• No severe active infection
• Pregnant women did not take antibiotics or antifungal drugs 30 days before fecal sample collection; No probiotic preparation was taken 2 weeks before sample collection; Never take drugs that may interfere with glucose and lipid metabolism
• No diseases affecting intestinal microecology
• No history of smoking and drinking
• The researchers evaluated those pregnant women expected to deliver more than 20 weeks
• Voluntarily participate in this clinical study and sign the informed consent form

Exclusion Criteria:

• With severe cardiopulmonary, hepatic and renal insufficiency
• With uncontrolled active infections 2 weeks before enrollment
• Subjects took antibiotics or antifungal drugs 30 days before sample collection; Take probiotics 2 weeks before sample collection; Have taken drugs that may interfere with glucose and lipid metabolism
• with diseases affecting intestinal microecology
• Smoking and drinking history
• With acute gastrointestinal ulcer
• Hemorrhagic constitution
• Other discomfort assessed by the investigato