Pregnancy Complications - A Probiotic Interventional Study

Pregnancy Complications - A Probiotic Interventional Study

Investigators hypothesize that

a) probiotics decrease the overall inflammatory state in the pregnant woman, especially in women with high risk pregnancies.

The main of the Project is to determine if dietary supplementation intake of probiotics are associated with a decreased inflammatory response in pregnant women, especially those with a history of previous preterm birth or preeclampsia, in a randomized clinical trial. Investigators also want to further investigate the relationship between intake of probiotics and the degree of inflammation in different compartments during pregnancy to see how the probiotic components affect the inflammatory state in the women.

Inclusion Criteria:

• Maternal age > or = 18 y
• Singleton pregnancy
• Nulli or multiparous without maternal intercurrent diseases or pregnant women with a history of spontaneous preterm delivery or pregnant women with a history of preeclampsia.

Exclusion Criteria

• Multiple pregnancy
• Gestational age > 17+6 weeks at first visit
• Chronic intermittent diseases (e.g. diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis, Chron disease, ulcerative colitis)
• Uterus malformations
• Immunomodulatory medication
• Hormonal treatment (e.g. crinone, progesterone)
• Subject disagrees to stop intake of other products containing probiotics during study time.
• Subject is unable to provide written informed consent