Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell.

Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders.

the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.

Inclusion Criteria:

1. Squamous cell carcinoma and basal cell carcinoma.
2. Incisional & excisional biopsies.
3. All the studied cases include sufficient materials for the immunohistochemical study 4. Complete clinical data

Exclusion Criteria:

1. Patients with a history of preoperative chemotherapy and/or radiotherapy.
2. Insufficient or tiny tissue biopsies.

Blocks obtained from cutaneous basal and squamous cell carcinoma tissue from 50 patients.