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Remimazolam is a newly introduced intravenous anesthetic, with rapid onset and offset. Although it is known to cause less hemodynamic instability, the incidence hypotension is the one of the most frequent adverse events with its use. For anesthetic induction, remimazolam can be used either as bolus dose or as continuous infusion.
This study is aimed to investigate the incidence of hypotension after anesthetic induction with bolus (0.14-0.33 mg/kg) or continuous (12 mg/kg/hr) remimazolam administration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bolus | Experimental | Anesthetic induction with bolus remimazolam administration |
|
| Continuous | Experimental | Anesthetic induction with continuous remimazolam administration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remimazolam bolus | Drug | Remimazolam bolus 0.14-0.33 mg/kg 0.25-0.33 mg/kg, <40 years 0.19-0.25 mg/kg, 60-80 years 0.14-0.19 mg/kg, >80 years |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of hypotension | Systolic pressure below 90 mmHg | 10 minutes after anesthetic induction |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of bradycardia | heart rate below 40 beats per minute | 10 minutes after anesthetic induction |
| The lowest systolic blood pressure | The lowest systolic blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cho E Ah, PhD | Contact | 82-2001-4657 | eunahthereal@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Cho E Ah | Kangbuk Samsung Hospital | Principal Investigator |
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| Remimazolam continuous | Drug | Remimazolam 12 mg/kg/hr |
|
| 10 minutes after anesthetic induction |
| Number of participants with vasoactive drug use | Use of vasoactive drug for the blood pressure or the heart rate management | 10 minutes after anesthetic induction |
| Time to loss of consciousness | Time from drug administration to loss of consciousness | 10 minutes after anesthetic induction |
| Dosage of remimazolam | Total dose or remimazolam used for anesthetic induction | 10 minutes after anesthetic induction |