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We plan to evaluate the potential of binaural beat stimulation as a cost-effective tool to improve perioperative patient outcome. Preoperative anxiety and postoperative neurocognitive disorders are two major issues patients have to deal with in the perioperative period. In this context, preoperative stress and anxiety are independent risk factors for postoperative neurocognitive disorders. The primary goal of our proposed study therefore is to reduce preoperative anxiety by stimulating patients with binaural beats. As binaural beats might also entrain brainwaves, the secondary goal of the study is to investigate whether binaural beats can induce alpha oscillatory activity during emergence from anesthesia. This type of oscillation has been demonstrated to be protective for postoperative neurocognitive disorders and might therefore complement the effects of preoperative anxiety reduction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Control Group, no Intervention received | |
| Preop Stimulation | Experimental | Binaural Beat Stimulation preoperatively |
|
| Postop Stimulation | Experimental | Binaural Beat Stimulation postoperatively |
|
| Pre- & Postop Stimulation | Experimental | Binaural Beat Stimulation pre- and postoperatively |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Binaural Beat Stimulation | Other | During binaural beats stimulation both ears receive a tone which varies slightly in its frequency. If the left ear is stimulated with a sinusoidal wave of 98 Hz and the right ear with a sinusoidal wave of 108 Hz, the brain will perceive this stimulation as a single tone at the mean frequency of 103 Hz. The amplitude of the perceived tone will fluctuate with a frequency that is equal to the difference of the two initial tones, i.e., 10 Hz |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of preoperative anxiety | Binaural beat stimulation before surgery can reduce preoperative anxiety | Assessments will take place one day before surgery as well as before administration of the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Increase of EEG alpha-band power during anesthesia emergence | Binaural beat stimulation during anesthesia emergence can increase or stabilize EEG alpha-band power. | Analysis will include the last 20 minutes of surgical procedure until patients are responsive again |
| Lower incidence of perioperative neurocognitive disorders |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julian Ostertag, MSc | Contact | +4941408681 | julian.ostertag@tum.de |
| Name | Affiliation | Role |
|---|---|---|
| Stephan Kratzer, Dr. | Klinik für Anästhesiologie und Intensivmedizin | Principal Investigator |
| Gerhard Schneider, Prof. | Klinik für Anästhesiologie und Intensivmedizin | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Technische Universität München | Recruiting | München | München (Stadt) | 80686 | Germany |
All recorded data may be shared with collaborating researchers
Data will be available starting March 2023.
Researchers who agree to collaborate on the project will have access to our protected server and can access all recorded data.
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2. Reduced preoperative anxiety and/or increased or stabilized alpha oscillations during anesthesia emergence are correlated with a lower incidence of perioperative neurocognitive disorders. |
| Incidence of perioperative neurocognitive disorders will be assessed during the patients stay in the PACU as well as one day post surgery |
| Matthias Kreuzer, Dr. |
| Klinik für Anästhesiologie und Intensivmedizin |
| Principal Investigator |