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Prospective randomized study investigating the effect of postoperative oxygen delivery on diaphragmatic function. Two different modalities of oxygen delivery will be compared: high flow nasal cannula versus standard oxygen therapy with facial mask
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high flow nasal cannula | Experimental | Two hours after extubation patients will received high flow nasal cannula oxygenation therapy for 24 hours |
|
| Standard oxygen therapy | Active Comparator | Two hours after extubation patients will received standard oxygenation therapy for 24 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High flow nasal cannula | Device | A device able to delivery high flow oxygen therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of diaphragmatic dysfunction | Ultrasound evaluation of diaphragmatic dysfunction | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pulmonary complication | Incidence of postoperative pulmonary complication | 7 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Days without oxygen support | 7 days |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Università di Ferrara | Ferrara | 44121 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40706477 | Derived | Fogagnolo A, Grasso S, Dres M, Azzolina D, Dalla Corte F, Dolci G, Tamburini N, De Paoli G, Murgolo F, Pedarzani E, Andalo A, Volta CA, Savino S. Impact of early high flow nasal oxygen on diaphragmatic function and pulmonary complications after thoracic surgery: A randomized clinical trial. J Clin Anesth. 2025 Sep;106:111945. doi: 10.1016/j.jclinane.2025.111945. Epub 2025 Jul 23. |
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Study dataset will be shared in anonymous form under reasonable request
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Facial mask | Device | standard oxygen therapy |
|