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To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).
This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest.
The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxygen first | Experimental | Optiflow with an inspired fraction of oxygen of 100% in the first seance Optiflow with an inspired fraction of oxygen of 21 % in the second seance |
|
| Air first | Experimental | Optiflow with an inspired fraction of oxygen of 21 % in the first seance Optiflow with an inspired fraction of oxygen of 100 % in the second seance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optiflow with an inspired fraction of oxygen of 100% | Device | Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100% |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effects of high flow nasal cannula on strapping induced type of dyspnea | Evaluated by visual annylogic scale | One hour |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the effect of the high flow by nasal cannula with and without oxygen on an experimental dyspnea, evaluated by the differences of changes in the visual analogic scale | Evaluated by visual annylogic scale | One hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Capucine Morelot-Panzini, Doctor | Service de Pneumologie de la Pitié-Salpétrière | Principal Investigator |
| Thomas Similowski, PHD | Service de Pneumologie de la Pitié-Salpétrière | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie et de Réanimation | Paris | 75013 | France | |||
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| ID | Term |
|---|---|
| D004417 | Dyspnea |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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|
| Optiflow with an inspired fraction of oxygen of 21% | Device | Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21% |
|
|
| Service de Pneumologie et Réanimation Médicale |
| Paris |
| 75013 |
| France |
| D013568 | Pathological Conditions, Signs and Symptoms |