Effects of Visual Reconstruction on Brain Function and Structure in Children With Congenital Cataract

Effects of Visual Reconstruction on Brain Function and Structure in Children With Congenital Cataract

Children have considerable plasticity of the visual system during the formation and maturation of various visual functions at different ages. Congenital cataracts are the leading cause of treatable blindness in children. With the continuous improvement of surgical approaches and surgical techniques, the success rate of congenital cataract surgery has been significantly improved clinically, and the visual function of children has been significantly improved after surgery. However, to date, there has been no experimental study of specific changes in the brain before and after surgery in children with congenital cataracts to explore its relationship with visual reconstruction. We aim to investigate the effects of congenital cataract surgery on the brain function and structure of children through preoperative and postoperative analysis and comparison of brain imaging such as BOLD-fMRI and DTI, and provide new ideas for the clinical treatment and prognostic assessment of this disease.

Inclusion Criteria:

• Children with congenital cataracts

Exclusion Criteria:

• Other oculo-cerebral and systemic diseases that may affect the outcome