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The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Food-Print Main Arm | Other | Functional Magnetic Resonance Imaging (pCASL-MRI) after Caloric and Volumetric stimulus in lean patients will be performed on all patients in the study |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional Magnetic Resonance Imaging (pCASL-MRI) | Other | MRI's will be performed at multiple points on each visit day. |
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in Cerebral Blood Flow related to hypothalamus | The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the hypothalamic area. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral Bloodflow related in multiple brain areas | The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the other brain areas related to food intake regulation. | 1 month |
| Cerebral Blood Flow between three stimuli |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Megan Schaefer | Contact | 507-266-6004 | RSTINDIVOBESITY@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Andres Acosta, MD, PhD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic Rochester | Recruiting | Rochester | Minnesota | 55905 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| C038767 | immunoglobulin B |
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| Intragastric Balloon | Other | Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI. |
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| Elemental Meal | Other | Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI. |
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| Hedonic Meal | Other | Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI |
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The mean difference in cerebral blood flow (CBF) between the 3 different stimuli. |
| 1 month |
| Hormone level | Differences in hormones levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) at each of the stages (I.e., baseline, fullness, maximal fullness) after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other. | 1 month |
| comparison of calories | Correlation the caloric consumption to fullness, maximal fullness with degree of cerebral blood flow(CBF) change on PASL MRI. | 1 month |
| calorie corellation to hormones | Correlation the caloric consumption to fullness, maximal fullness with changes in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin). | 1 month |
| hormone level comparison | Differences in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) between fullness and hunger after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other. | 1 month |
| Time differences in stimuli | Differences in time to next meal after maximal fullness after the three different stimulations. | 1 month |
| Caloric consumption differences in stimuli | Differences in the caloric consumption after maximal fullness after the three different stimulations. | 1 month |
| FitBit measured Physical Activity | Measurement of daily physical activity during free-living conditions measured through the use of FitBit tracker over the duration of the study. | 1 month |