A Registered Cohort Study on Neurodegenerative Associated With Sleep Disorder.

A Registered Observational Cohort Study on Neurodegenerative Associated With Sleep Disorder.

Cognitive impairment often appears in neurodegenerative diseases, and it is expected to further study the mechanism of sleep disorders associated with the progression of neurodegenerative diseases by exploring the clinical manifestations, imaging, and biological marker changes of sleep disorders in neurodegenerative diseases.

Inclusion Criteria:

1. clinical diagnosis of neurodegenerative disease.
2. patients experience insomnia, excessive drowsiness, or confusion at night.
3. Patients experience frequent awakenings, daily sleep episodes, or nocturnal confusion.
4. The presence of one or more of the following characteristics: a. wandering at night with inappropriate activity; b. agitation, combativeness; c. confusion, disorientation, or marked delirium.
5. Polysomnographic monitoring showed the following two conditions: a. poor sleep efficiency, increased number and duration of awakenings; b. multiple sleep latency tests showed increased daytime sleepiness.
6. Presence of other medical symptoms that do not indicate the primary disease.
7. Other sleep disorders (e.g., periodic limb movement disorders, obstructive sleep apnea syndrome) may be present, but do not explain the patient 's main symptoms.
8. any of the above can be diagnosed

Exclusion Criteria:

1. Patients with other neurological disorders.
2. Pregnant or lactating women.