Effect of Gui-Lu-Er-Xian-Jiao-Wan on Intradialytic Hypotension

Effect of Gui-Lu-Er-Xian-Jiao-Wan on Intradialytic Hypotension: a Randomized Crossover Pilot Trial

Intradialytic hypotension (IDH), a common complication during hemodialysis (HD) could increase patients' morbidity and mortality. Previous studies considered that some Chinese herbal medicine (CHM) plays a complementary role in reducing the frequency of IDH. This trial is aimed to investigate the effect of Gui-Lu-Er-Xian-Jiao-Wan (GLEXJW) in patients with intradialytic hypotension.

Inclusion Criteria:

• End stage renal disease treated with hemodialysis for ≥3 months
• Receive a standard thrice-weekly hemodialysis schedule
• More than 25% of hemodialysis sessions complicated by intradialytic hypotension

Exclusion Criteria:

• Active malignancy
• Life-threatening conditions
• Pregnancy
• Recent participation in another clinical trial for intradialytic hypotension
• History of hypersensitivity or contraindication to herbal medicine