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| Name | Class |
|---|---|
| Nationtial Institute of Nutrition and Health, China CDC | OTHER |
| SAS Institute | INDUSTRY |
| Veeva Systems | INDUSTRY |
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The aim of the study is to evaluate the impact of different delivery modes on specific macronutrient components in human milk.
The main objective of the study is to explore the differences in human milk composition from mothers delivering by Caesarean-section and normal vaginal deliveries. To further associate the differences found in human milk composition to infant outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Caesarean-section | 125 subjects will be selected who have delivered infants by Caesarean-section. | ||
| Normal delivery | 125 subjects will be selected who have delivered infants by vaginal/normal deliveries |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in HMO from mothers' milk who delivered by Caesarean-section and normal vaginal deliveries. | HMO will be analyzed by HPLC-FLD | baseline (no primary mothers' milk collection, but from existing human milk samples) |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in human milk fat from mothers who delivered by Caesarean-section and normal vaginal deliveries. | Fatty acid will be analyzed by GC-FID | baseline (no primary collection, but from existing human milk samples) |
| Differences in human milk proteins from mothers who delivered by Caesarean-section and normal vaginal deliveries. |
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Inclusion Criteria:
Exclusion Criteria:
1) Incomplete information either for the subject or the sample collected.
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The study population of interest is mothers that have delivered at full term (>37 weeks of gestation) who have already provided human milk samples collected within China CDC's cross sectional multi-centric human milk study conducted in China.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health | Beijing | China |
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human milk samples have already been collected within China CDC's cross sectional multi-centric human milk study conducted in China
Proteins will be analyzed by Ultra-high phase liquid chromatography |
| baseline (no primary collection, but from existing human milk samples) |
| Differences in human milk gangliosides from mothers who delivered by Caesarean-section and normal vaginal deliveries. | gangliosides will be analyzed by GC-MS | baseline (no primary collection, but from existing human milk samples) |
| Association of the differences in human milk composition with subject-reported outcomes | The subject-reported outcomes were existing information in the questionnaires | baseline (no primary collection, but from the existing questionnaires) |