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A split-belt treadmill (SBT) is a treadmill with two belts, whereby each leg can be driven at a different speed. Previous work by the investigators showed that one session of SBT training improved turning while multi-tasking and reduced FOG in PwPD tested in the laboratory. However, subsequent work raises questions as to whether treadmill improvements following repeated SBT training generalize to overground situations in the long term. Therefore, in this study, the investigators will perform a four-week SBT intervention with added practice of everyday turning scenarios (SBT+CP) or placebo exercise (SBT+PL), and study its effects on FOG in both the laboratory and at home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SBT+CP | Experimental | Split-belt training + complex task practice |
|
| SBT+PL | Active Comparator | Split-belt training + static exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Split-belt treadmill training | Behavioral | Split-belt walking with various speed ratios between the two legs, applied with random-block practice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage Time Frozen during turning in place | Percentage Time Frozen scored from video of rapid alternating full turns in place. Based on earlier work showing immediate effects of SBT training on FOG during this task. | up to 8 weeks post intervention |
| Time to complete Timed Up and Go (TUG) | Overall time to complete the Timed Up and Go task. The training is expected to improve multiple transitions between straight walking and turning and should be reflected in the overall task time. | up to 8 weeks post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage Time Frozen over all FOG-provoking tasks | Percentage Time Frozen scored from videos of Turning in place,TUG, Hotspot door and Hotspot personalized. | up to 8 weeks post intervention |
| Percentage Time Frozen over 1-week free-living monitoring |
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| Name | Affiliation | Role |
|---|---|---|
| Alice Nieuwboer, PhD | KU Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Movement and Rehabilitation Sciences (FaBeR) | Leuven | 3001 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34939224 | Background | D'Cruz N, Seuthe J, De Somer C, Hulzinga F, Ginis P, Schlenstedt C, Nieuwboer A. Dual Task Turning in Place: A Reliable, Valid, and Responsive Outcome Measure of Freezing of Gait. Mov Disord. 2022 Feb;37(2):269-278. doi: 10.1002/mds.28887. Epub 2021 Dec 22. | |
| 33101174 | Background | D'Cruz N, Seuthe J, Ginis P, Hulzinga F, Schlenstedt C, Nieuwboer A. Short-Term Effects of Single-Session Split-Belt Treadmill Training on Dual-Task Performance in Parkinson's Disease and Healthy Elderly. Front Neurol. 2020 Sep 30;11:560084. doi: 10.3389/fneur.2020.560084. eCollection 2020. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Randomised single-blind parallel-group study
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Participants receive training in both arms and will be blinded to the exercise group differences.
Outcomes assessor will be blinded to the group allocation and will carry out all assessments in a standardized manner irrespective Investigator will perform blinded analyses of the data
| Complex task practice | Behavioral | Overground gait flexibility training with added cognitive tasks |
|
| Static balance exercise | Behavioral | Mindfulness and breathing combined with static balance exercises |
|
Percentage Time Frozen estimated from machine learning algorithm using free-living sensor data captured over 1 week.
| up to 8 weeks post intervention |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |