Comparison of the Effects of Tenoxicam and Paracetamol on Postoperative Pain

Comparison of the Efficacy of Tenoxicam, Paracetamol (Acetaminophen), and Tenoxicam-Paracetamol Combination on Postoperative Pain in Double-Jaw Surgery Patients

Postoperative pain is generally caused by inflammation and oedema related to tissue trauma. Surgical tissue trauma is caused by many factors such as cotery-related burns, surgical incisions, dissections, and instrumental procedures like cutting, stretching, or compression.

The pain stimulus is triggered by mediators released by the traumatic tissue and transmitted to the spinal cord and then to the upper centres of the brain. Tenoxicam is an analgesic, anti-inflammatory, and antipyretic drug with a long duration of action, included in the oxicam subgroup of NSAIDs. Tenoxicam has been studied and found effective for many rheumatic diseases such as rheumatoid arthritis, ankylosing spondylitis, gout, extra-articular disorders, bursitis, tendonitis, and osteoarthritis. The primary aim of this study was to compare the effects of tenoxicam, paracetamol, and tenoxicam-paracetamol combination analgesic applications on the postoperative VAS score of double-jaw surgery patients. The secondary aim was to investigate the effects of these interventions on the number of both opioid and rescue analgesic drug consumption postoperatively.

Inclusion Criteria:

• Patients between 18-50 aged of both genders who were scheduled for elective bimaxillary surgery
• Classified as American Society of Anesthesiologists (ASA) risk class I or II

Exclusion Criteria:

• having liver or renal dysfunction
• coagulopathy disorder,
• having psychiatric or medical conditions that might impair communication or compliance with the study procedures
• having allergy or contra-indications to the study drugs .pregnancy.
• patients who were planned to undergo additional simultaneous surgical procedures such as genioplasty were not included in the study. -