Prospective Real World Study Of Upadacitinib in Ulcerative Colitis (PROFUNDUS)
Prospective Real World Study Of Upadacitinib in Ulcerative Colitis (PROFUNDUS)
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. This study will assess how safe and effective upadacitinib is in treating adult participants with moderate to severe ulcerative colitis (UC). Adverse events and change in disease activity will be assessed.
Upadacitinib is a drug approved for the treatment of Ulcerative colitis (UC). All study participants will receive upadacitinib as prescribed by their study doctor in accordance with approved local label. Approximately 1000 adult participants will be enrolled worldwide.
Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 3 years.
There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
Inclusion Criteria:
Exclusion Criteria:
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D. 1115, Argentina
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D. 1280, Argentina
Córdoba, 5016, Argentina
Edmonton, Alberta T5R 1W2, Canada
Hamilton, Ontario L8S 4K1, Canada
North York, Ontario M6A 3B4, Canada
Montreal, Quebec H1T 2M4, Canada
Montreal, Quebec H4A 3J1, Canada
St-Priest-en-Jarez, Pays de la Loire Region 42270, France
Epagny Metz Tessy, 74370, France
Neuilly-sur-Seine, Île-de-France Region 92200, France
Kassel, Hesse 34117, Germany
Ludwigshafen am Rhein, Rhineland-Palatinate 67067, Germany
Leipzig, Saxony 04105, Germany
Lübeck, Schleswig-Holstein 23538, Germany
Berlin-Zehlendorf, 14163, Germany
Athens, 10676, Greece
Elm Park, Dublin D04 T6F4, Ireland
Beer Ya'akov, Central District 70300, Israel
Castellana Grotte, Bari 70013, Italy
Rome, Roma 00168, Italy
Funchal, Madeira 9000-177, Portugal
Lisbon, 1349-019, Portugal
Zone 51, Baladiyat ar Rayyan, Qatar
Las Palmas de Gran Canaria, Las Palmas 35010, Spain
San Cristóbal de La Laguna, Santa Cruz De Tenerife 38320, Spain
Hull, East Riding Of Yorkshire HU3 2JZ, United Kingdom
Kettering, Northamptonshire NN16 8UZ, United Kingdom
Oxford, Oxfordshire OX3 9DU, United Kingdom
Belfast, BT16 1RH, United Kingdom