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The main aim and scope of this study is making comparison about the thrombelastography and coagulation function in patients before and after the total knee arthroplasty with intra-articular tranexamic acid administration. The results may identify the influence of the intra-articular tranexamic acid administration on the relative coagulability monitoring.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tranexamic acid group | During the total knee arthroplasty, the patients received a 2-g retrograde injection of tranexamic acid through the drain after closure, with subsequent clamping of the drain for 6 hours. |
| |
| Non-tranexamic acid group | During the total knee arthroplasty, the patients did not receive tranexamic acid administration. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid | Drug | During the total knee arthroplasty, the patients received a 2-g retrograde injection of tranexamic acid through the drain after closure, with subsequent clamping of the drain for 6 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| R time | R time is the period from the initiation of the thrombelastography test till the beginning of the clot formation. | day0 (pre-operative) |
| R time | R time is the period from the initiation of the thrombelastography test till the beginning of the clot formation. | day3 (post-operative) |
| K time | K time is the period from the start of the clot formation to the curve reaches amplitude of 20mm in the thrombelastography. | day0 (pre-operative) |
| K time | K time is the period from the start of the clot formation to the curve reaches amplitude of 20mm in the thrombelastography. | day3 (post-operative) |
| Alpha angle | Alpha angle is the angle between the baseline and the tangent to the thrombelastography curve through the starting point of coagulation. | day0 (pre-operative) |
| Alpha angle | Alpha angle is the angle between the baseline and the tangent to the thrombelastography curve through the starting point of coagulation. | day3 (post-operative) |
| Maximal amplitude (MA) | Maximal amplitude (MA) is a direct measure of the highest point on the thrombelastography curve and represents clot strength. | day0 (pre-operative) |
| Measure | Description | Time Frame |
|---|---|---|
| Prothrombin time (PT) | Prothrombin time (PT) is one of the parameters which reflects the coagulation function. | day0 (pre-operative) |
| Prothrombin time (PT) | Prothrombin time (PT) is one of the parameters which reflects the coagulation function. |
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Inclusion Criteria:
Exclusion Criteria:
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The patients received primary total knee arthroplasty.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Du | Contact | 86-13817371926 | sato316@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Lin Du | RenJi Hospital | Study Chair |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Maximal amplitude (MA) | Maximal amplitude (MA) is a direct measure of the highest point on the thrombelastography curve and represents clot strength. | day3 (post-operative) |
| Clot index (CI) | Clot index (CI) represents the haemostasis profile and is calculated based on R time, K time, Alpha angle and MA parameters. | day0 (pre-operative) |
| Clot index (CI) | Clot index (CI) represents the haemostasis profile and is calculated based on R time, K time, Alpha angle and MA parameters. | day3 (post-operative) |
| day3 (post-operative) |
| Activated partial thromboplastin time (APTT) | Activated partial thromboplastin time (APTT) is one of the parameters which reflects the coagulation function. | day0 (pre-operative) |
| Activated partial thromboplastin time (APTT) | Activated partial thromboplastin time (APTT) is one of the parameters which reflects the coagulation function. | day3 (post-operative) |
| Hemoglobin in g/L | Hemoglobin is a parameter which reflects the blood loss or anemia. | day0 (pre-operative) |
| Hemoglobin in g/L | Hemoglobin is a parameter which reflects the blood loss or anemia. | day3 (post-operative) |
| Red blood cell specific volume (HCT) | Red blood cell specific volume (HCT) is a parameter which reflects the ratio of the red blood cells in the whole blood. | day0 (pre-operative) |
| Red blood cell specific volume (HCT) | Red blood cell specific volume (HCT) is a parameter which reflects the ratio of the red blood cells in the whole blood. | day3 (post-operative) |
| Fibrinogen in g/L | Fibrinogen is one of the parameters which reflects the coagulation function. | day0 (pre-operative) |
| Fibrinogen in g/L | Fibrinogen is one of the parameters which reflects the coagulation function. | day3 (post-operative) |
| Platelet count in 10^9g/L | Plstelet count is a parameter which reflects the amount of the platelet in the whole blood. | day0 (pre-operative) |
| Platelet count in 10^9g/L | Plstelet count is a parameter which reflects the amount of the platelet in the whole blood. | day3 (post-operative) |