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Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.
Lidocaine was applied in the operation of colorectal tumor patients, and the effect on the postoperative microenvironment and micrometastasis of the patients was observed by detecting the stress, immunity, vascular tumor regeneration, inflammation, etc. of the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine is used in radical resection of colorectal tumors. | Experimental | Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation | Drug | Administer 1.5 mg/kg lidocaine |
| Measure | Description | Time Frame |
|---|---|---|
| the concentration of tumor micrometastasis markers were determined by ELISA | the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA | 3 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| the concentration of stress hormones were determined by ELISA | the concentration of EPI and NE were determined by ELISA | 3 days after surgery |
| the concentration of inflammatory factor were determined by ELISA |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| hongsheng chen | Chair | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital of Nantong University | Nantong | Jiangsu | 226001 | China |
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|
the concentration of IL-6,IL-8,TNF-α were determined by ELISA
| 3 days after surgery |
| the concentration of angiogenesis factors were determined by ELISA | the concentration of VEGF was determined by ELISA | 3 days after surgery |
| the concentration of immune indexes were determined by ELISA | the concentration of B lymphocytes, T lymphocytes, NK cells, macrophages were determined by ELISA | 3 days after surgery |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007249 | Inflammation |
| D061206 | Neoplasm Micrometastasis |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009362 | Neoplasm Metastasis |
| D009385 | Neoplastic Processes |
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