External Evaluation of Vancomycin Population Pharmacokinetic Models

External Evaluation of Vancomycin Population Pharmacokinetic Models and Development of Continuous Infusion Dosing Recommendations

All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded.

Seven pharmacokinetic models' predictive performance will be evaluated on this database.

Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.

Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.

Inclusion Criteria:

• All patients hospitalized in Brest University Hospital,
• treated with vancomycin and receiving pharmacological monitoring
• between 1rst January 2019 and 1rst January 2021

Exclusion Criteria:

• Missing data on vancomycin administration
• Refusal to be included in this study
• Hospitalisation in ICU