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This observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for ICU patients treated with continuous vancomycin infusion.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plasma vancoymcin measurements | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Time (days) from start of treatment to first measurement of a plasma vancomycin concentration between 20 and 25 mg/mL | The title is a full description. | Until the end of treatment or discharge from unit |
| Relationship between time to intended concentration (15-20 mg/L) and adherence to the dosing protocol (% complete adherence). | For each patient the actually administired dose of vancomycin will be compared to the recommendation in the dosing protocol. The time to the intended concentration will be compared between patients with 100% adherence to the recommendations and for patients with dosing not following the recommendations. | Until the end of treatment or discharge from unit |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of the total treatment duration with the intended plasma concentration 15-20 mg/L. | The title is a full description. | Until the end of treatment or discharge from unit |
| Relationship between Percentage of the total treatment duration with the intended plasma concentration (15-20 mg/L) and adherence to the dosing protocol. |
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Inclusion Criteria:
- Start of continuous vancomycin infusion during the course of intensive care and at least one measurement of plasma concentration.
Exclusion Criteria:
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ICU patients.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska University Hospital Solna | Stockholm | 17176 | Sweden |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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The title in combination with the description of outcome 2 is a sufficient description. |
| Until the end of treatment or discharge from unit |
| D013568 |
| Pathological Conditions, Signs and Symptoms |