This study is being carried out to find out whether there is reduction in vancomycin-induced kidney injury (nephrotoxicity) when vancomycin is given as intermittent versus continuous infusion.

This study will recruit 220 subjects from 2 hospitals over a period of 3 years.

Participants are invited if they have an infection that requires prolonged vancomycin therapy (> more than 10 days).

Inclusion Criteria:

• Adults aged 21-80 years
• Documented infection requiring prolonged (> 10 days) of vancomycin therapy
• Creatinine clearance > 50 ml/min (using Cockroft-Gault equation)

Exclusion Criteria:

• Patient already received 7 days or more of vancomycin therapy
• Pregnancy
• Severe burns > 40% body surface area
• Spinal cord injuries
• Participation in another interventional trial in previous 30 days
• Inability to obtain informed consent