Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases

Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases

With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.

Inclusion Criteria:

• The diagnosis of metabolic diseases were confirmed;
• Be able to understand the process of the research;
• Volunteer for participation and be able to sign the informed consent.

Exclusion Criteria:

• Age <18 yrs or >80yrs;
• Patients with primary and secondary glomerular diseases
• Patients with other comorbidities that could affect the volume or the components of the kidney, such as renal cysts, polycystic kidney disease, medullary sponge kidney, hydronephrosis, renal artery stenosis, renal vein thrombosis and/or renal tumors;
• Contraindications for MRI examination;
• Pregnant or lactation patients;
• Patients with unstable vital signs, failure of other organs or dysphoria.