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| Name | Class |
|---|---|
| Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | OTHER |
| The Queen Elizabeth Hospital | OTHER |
| Umberto I Mauriziano Hospital, Turin, Italy | UNKNOWN |
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Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Open liver resection | Non-obese or obese patients that underwent an open liver resection for all indications | ||
| Minimally invasive liver resection | Non-obese or obese patients that underwent a minimally invasive liver resection for all indications |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Minimally invasive liver resection | Procedure | A liver resection performed by minimally invasive (keyhole) surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Major complications | Severe complications (Clavien-Dindo grade 3a or higher) related to the surgical procedure | 30 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Overall complications | Overall complications related to the surgical procedure | 30 days postoperatively |
| Length of hospital stay | The length of hospital stay for the surgical procedure |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients who underwent an elective liver resection at 20 hepatobiliary referral centres between January 2009 and December 2019
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Poliambulanza Istituto Ospedaliero | Brescia | 25124 | Italy |
The data of this study will be available from the corresponding author, Professor Mohammed Abu Hilal, upon reasonable request. The data are not publicly available since this could compromise the privacy of research participants.
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| ID | Term |
|---|---|
| D008113 | Liver Neoplasms |
| D009765 | Obesity |
| D050177 | Overweight |
| D005234 | Fatty Liver |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
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| Oslo University Hospital and Institute of Medicine, University of Oslo, Oslo, Norway |
| UNKNOWN |
| Padua University Hospital, Padua, Italy | UNKNOWN |
| IRCCS San Raffaele | OTHER |
| University Hospital of Girona Dr. Josep Trueta | NETWORK |
| Clinica Universidad de Navarra, Pamplona, Spain | UNKNOWN |
| Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France | UNKNOWN |
| Groeninge Hospital, Kortrijk, Belgium | UNKNOWN |
| University Hospital Southampton NHS Foundation Trust | OTHER |
| Riuniti Hospital, Polytechnic University of Marche, Ancona, Italy | UNKNOWN |
| Universita di Verona | OTHER |
| Virginia Mason Medical Center, Seattle, USA | UNKNOWN |
| University of California, San Francisco | OTHER |
| Moscow Clinical Research Centre, Moscow, Russia | UNKNOWN |
| Catholic University of the Sacred Heart | OTHER |
| Antoine Béclère Hospital, Paris, France | UNKNOWN |
| IRCCS Azienda Ospedaliero-Universitaria di Bologna | OTHER |
| University of Modena and Reggio Emilia | OTHER |
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| 30 days postoperatively |
| R0 resection margin | Proportion of patients in whom a microscopically radical resection of both the primary colorectal carcinoma and the liver metastases was performed. Proportion of patients in whom a microscopically radical resection was performed | 30 days postoperatively |
| Intraoperative blood loss | Intraoperative blood loss in milliliters | During the surgical procedure |
| Operative time | Operative time in minutes | During the surgical procedure |
| Conversion to open surgery | Intra-operative conversion to an open or hand-assisted procedure in the minimally invasive group | During the surgical procedure |
| Respiratory complications | All respiratory complications | 30 days postoperatively |
| Wound-related complications | All wound-related complications | 30 days postoperatively |
| Post-hepatectomy liver failure | Occurrence of post-hepatectomy liver failure (ISGLS definition and classification) | 30 days postoperatively |
| Bile leak | Occurrence of bile leak (ISGLS definition and classification) | 30 days postoperatively |
| Ascites | Occurrence of ascites | 30 days postoperatively |
| Mortality | Postoperative mortality | 90 days postoperatively |
| Red blood cell transfusion | Intraoperative red blood cell transfusion | During the surgical procedure |
| D008107 |
| Liver Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |