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The general aim of the research is to provide scientific evidence that vibro-tactile stimulation (VTS) represents a non-invasive form of neuromodulation that can induce measurable improvements in the speech of patients with laryngeal dystonia (LD) - also called spasmodic dysphonia (SD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low dose / continuous VTS | Experimental | Low dose refers to receiving VTS 5 times/week for 20 minutes each; non-task-specific, constant stimulation during non-speech |
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| Low dose / speech activated VTS | Experimental | Low dose refers to receiving VTS 5 times/week for 20 minutes each; VTS during connected speech |
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| High dose / continuous VTS | Experimental | High dose refers to receiving VTS 7 times/week for 20 minutes each; non-task-specific, constant stimulation during non-speech |
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| High dose / speech activated VTS | Experimental | High dose refers to receiving VTS 7 times/week for 20 minutes each; VTS during connected speech |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vibro-tactile stimulation (VTS) | Device | To apply vibro-tactile stimulation, participants will use a wearable device. It contains two vibratory motors (Precision MicrodrivesTM, Model 307 - 100) that are low-voltage (~1V), non-invasive and will be located approximately above the lateral portions of the thyroid cartilage. For this protocol, they vibrate at frequencies between 40 - 100 Hz (i.e., 100 times per second |
| Measure | Description | Time Frame |
|---|---|---|
| Change in perceived speech effort (PSE) | Speaker will assess effort themselves and assign an score (range: 0-10 with a score of '10' indicating most severe effort) | 24 months |
| Change in smoothed cepstral peak prominence (CPPS) | CPPS provides a measure of the strength of the fundamental frequency within background aperiodicity (physical unit is dB) | 24 months |
| Change in speech quality vector (SQV) (%) | A derived measure designed to understand if a participant's voice symptom improvement occurs across objective (CPPS) and subjective measures of speech (PSE). It is based on the relative change between two time points | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D055154 | Dysphonia |
| ID | Term |
|---|---|
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |