Lung Health of Early COPD: A Multi-center Cohort Study | NCT05466396 | Trialant

Lung Health of Early COPD: A Multi-center Cohort Study | NCT05466396 | Trialant

Sponsor/Collaborators Module

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Smokers with Pre-COPD		Smoking history ≥ 10 pack-years 0.7≤ FEV1/FVC<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)	Behavioral: smoking
Smokers with Mild-COPD		Smoking history ≥ 10 pack-years FEV1/FVC<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)	Behavioral: smoking
Non-Smokers with Pre-COPD		Smoking history < 10 pack-years or never-smokers 0.7≤ FEV1/FVC<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)
Non-Smokers with Mild-COPD		Smoking history < 10 pack-years or never-smokers FEV1/FVC<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)
Healthy Controls		Healthy volunteers without smoking history FEV1/FVC ≥ 0.8 and FEV1%pred ≥ 80% (post-bronchodilator)

Outcomes Module

Secondary Outcomes

Measure	Description	Time Frame
Lung function decline in smokers with Pre-COPD and Mild-COPD	FEV1 decline in smokers with Pre-COPD and Mild-COPD	2 years
Lung function decline in non-smokers with Pre-COPD and Mild-COPD	FEV1 decline in non-smokers with Pre-COPD and Mild-COPD

Other Outcomes

Measure	Description	Time Frame
Lung function decline and biomarkers in Pre-COPD and Mild-COPD patients	Association between FEV1 decline and biomarkers in blood, sputum or urine in Pre-COPD and Mild-COPD patients	2 years
Lung function decline and Image markers in Pre-COPD and Mild-COPD patients

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
40703223	Derived	Li W, Lei J, Li B, Tang X, Peng Y, Huang K, Yang T. Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study-Rational and Design. Int J Chron Obstruct Pulmon Dis. 2025 Jul 19;20:2561-2568. doi: 10.2147/COPD.S517185. eCollection 2025.

Condition Browse Module

Intervention Browse Module