Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis.
Based on the above reasons, we used the Delphi method,in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia.
Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Postoperative cholangitis | Patients who had conducted kasai procedure and suffered from postoperative cholangitis after surgery |
| |
| None postoperative cholangitis | Patients who had conducted kasai procedure and followed up in a clinic,at which time they didn't present signs of cholangitis |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous Antibodies | Drug | Treatment is usually performed with sensitive third-generation cephalosporins, and medication is adjusted according to blood culture results |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic cholangitis score | The values of the two groups' scores were calculated separately | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Score estimates for treatment of cholangitis | In the cholangitis group, the correlation between evaluation score and treatment was studied | Two years |
Not provided
Inclusion Criteria:
â‘ Admission time: 2019.01.01-2021.12.31;
â‘¡ The first diagnosis after discharge was cholangitis
Exclusion Criteria:
â‘ Cholangitis after non-Kasai procedure;
Not provided
Not provided
Not provided
Patients who had been conducted Kasai procedure have different outcomes. The clinical data of these patients who were diagnosed as cholangitis and were followed up in the clinic were collected in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xie Hua, Dr | Contact | +8613611573952 | xiehua3955@126.com | |
| Lu changgui, Dr | Contact | +8613611573952 |
| Name | Affiliation | Role |
|---|---|---|
| Tang weibing, Dr | Nanjing Children's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NJMU | Recruiting | Nanjing | Jiangsu | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001656 | Biliary Atresia |
| D002761 | Cholangitis |
| ID | Term |
|---|---|
| D001649 | Bile Duct Diseases |
| D001660 | Biliary Tract Diseases |
| D004066 | Digestive System Diseases |
| D004065 | Digestive System Abnormalities |
Not provided
Not provided
| ID | Term |
|---|---|
| D016756 | Immunoglobulins, Intravenous |
| ID | Term |
|---|---|
| D007074 | Immunoglobulin G |
| D007132 | Immunoglobulin Isotypes |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
Not provided
Not provided
Not provided
Not provided
Not provided
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007162 |
| Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |