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Better survival and prognosis of biliary atresia (BA) depend on early diagnosis and timely Kasai portoenterostomy. Identifying BA from other causes of infantile cholestasis at early stage of the disease still remains a major challenge. In this study, the investigators aim to develop and validate a scoring system to screen BA in infants with cholestasis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| derivation cohort |
| ||
| validation cohort |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biliary atresia screen score | Diagnostic Test | The investigators aim to develop a scoring system according to clinical, laboratory, imaging features of biliary atresia in the derivation dataset and tested in the validation datasets. |
| Measure | Description | Time Frame |
|---|---|---|
| Development and Validation a Screening Score for the biliary atresia in infantile cholestasis | Developed a scoring system according to clinical, laboratory, imaging features of BA and test it in the clinical work. The score system might including clay stool, γ-glutamyl transpeptadase, the results of ultrasound and subscales selected for logistic regression. The total score would sum all the subscales up.The investigators grade the patients with the cholestasis screen score to identify patients with biliary atresia. Patients with score ≤ 15 points considered to be the low-risk group, and patients with risk score > 15 points considered the high-risk group, and the score model has no maximum or minimum value. | 1 weeks |
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Inclusion Criteria:
Clinical diagnosis of neonatal cholestasis Age at first visit less than 90 days after birth
Exclusion Criteria:
Severe congenital malformation Subjects with missing data
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infants with cholestasis inclduing biliary atresia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yongjun Zhang, doctor | Contact | +8602125078310 | zhangyongjun@sjtu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | 200092 | China |
The investigators plan to share all the individual participant data information available to our cooperative hospitals through emails
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| ID | Term |
|---|---|
| D001656 | Biliary Atresia |
| ID | Term |
|---|---|
| D001649 | Bile Duct Diseases |
| D001660 | Biliary Tract Diseases |
| D004066 | Digestive System Diseases |
| D004065 | Digestive System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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