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Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated immuneresponse. Hypersenstivity pneumonitis is a common form of diffuse parenchymal lung diseases in Egypt .Pulmonary hypertension has been found as a complication of a number of diseases affecting the lung interstitium, including hypersensitivity pneumonitis, with subsequent affection of the life expectancy Rationale of the study: to find predictors for the development of pulmonary hypertension in patients with hypersensitivity pneumonitis
Cross sectional study included 60 patients with established diagnosis of HP , work up includes history of exposure, clinical examination, HRCT chest, ABGs,6MWD, desaturation degree , spirometry, echocardiography and right heart catheter in patients with high echo probability of PH.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HP without Pulmonary hypertion | No Intervention | HRCT chest , pulmonary functions and echocardiography | |
| HP with Pulmonary hypertion | Active Comparator | HRCT chest , pulmonary functions ,echocardiography and RT heart catheter in high echocardiographic probability of PH |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Right heart catheter | Procedure | Right heart catheterization was performed for 4 cases with high probability of pulmonary hypertension using multi-lumen swan ganz catheter. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of pulmonary hypertension in patients with HP | primary oucome | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasr alainy school of medicine | Cairo | 11562 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36759788 | Derived | Elnady MA, Elkorashy R, Nabil A, Ibrahim EK. Predictors of pulmonary hypertension in patients with hypersensitivity pneumonitis. BMC Pulm Med. 2023 Feb 9;23(1):61. doi: 10.1186/s12890-023-02347-1. |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D000542 | Alveolitis, Extrinsic Allergic |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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| D002318 |
| Cardiovascular Diseases |
| D017563 | Lung Diseases, Interstitial |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |