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The purpose of this study is to (1) assess how a competitive season of purposeful gameplay soccer heading in collegiate women soccer players is related to a blood biomarker for sports-related brain injury, plasma neurofilament light (NF-L), and (2) examine how a player's omega-3 status is related to plasma NF-L concentration changes during and after a competitive season of gameplay soccer heading.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Collegiate Women Soccer Players | National Collegiate Athletic Association (NCAA) players. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plasma Neurofilament Light (NF-L) | Other | Plasma NF-L is a biomarker of axonal brain injury following sports-related head impacts. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in plasma neurofilament light concentrations from baseline, during, and after a competitive season. | Plasma neurofilament light (pg/mL) is a biomarker of axonal brain injury following sports-related head impacts. | Baseline, 1 Months, 2 Months, 3 Months, 6 Months |
| Change in purposeful soccer heading frequencies from baseline, during, and after a competitive season. | HeadCount is a web-based, structured, self-administered questionnaire to assess longer-term heading frequencies (#) during competitive play and is administered bi-weekly. | Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 14 weeks |
| Change in Omega-3 status from baseline, during, and after a competitive season. | Omega-3 Index (%) is the omega-3 fatty acid content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) within membrane of red blood cell. It is expressed as EPA+DHA as a percent of total identified fatty acids. | Baseline, 1 Months, 2 Months, 3 Months, 6 Months |
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Inclusion Criteria:
Exclusion Criteria:
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Collegiate women soccer players who actively compete at the NCAA Division 1-A competition level.
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| Name | Affiliation | Role |
|---|---|---|
| Aaron F Carbuhn, PhD | University of Kansas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Missouri Kansas City | Kansas City | Missouri | 64108 | United States | ||
| Rockhurst University |
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Plasma
| Omega-3 Index | Other | Omega-3 Index is the omega-3 fatty acid content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) within the erythrocyte cell membrane. It is expressed as EPA+DHA as a percent of total identified fatty acids. |
|
| HeadCount Questionnaire | Other | HeadCount is a web-based, structured, self-administered questionnaire to assess longer-term heading exposure during competitive play and is administered bi-weekly. |
|
| Kansas City |
| Missouri |
| 64110 |
| United States |
| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| C537987 | Charcot-Marie-Tooth disease, Type 1F |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
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