Futility

The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp

Assignment: Each study subject will serve as their own control. The order of the visits will be randomized.

Delivery of Interventions:

Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories.

During the inpatient study, the subjects will

Undergo a 16-hour kisspeptin infusion Undergo a hyperglycemic clamp

• over the age of 17
• normal pubertal development
• regular menstrual cycles
• stable weight for previous three months
• normal body mass index
• blood pressure systolic BP < 140 mm Hg, diastolic < 90 mm Hg
• normal hemoglobin
• hemoglobin A1C < 6.5%
• BUN, creatinine not elevated
• AST, ALT < 3x upper limit of normal
• negative serum pregnancy test

Exclusion Criteria:

• active illicit drug use,
• history of a medication reaction requiring emergency medical care,
• difficulty with blood draws.
• history of hypertension, diabetes, heart disease, high cholesterol, cancer, or clotting disorders.
• history of chronic disease that has required hospitalization
• recent use of prescription medications which interfere with metabolism or reproduction (recent = within 5 half-lives of the drug) unless it is birth control
• history of diabetes in a first degree relative
• hyperlipidemia by fasting lipid panel