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The Bronx-Valve Registry is designed to collect and assess data on all patients with valvular diseases referred to Montefiore Medical Center for echocardiographic exams. Valvular heart disease (VHD) is a major focus of cardiovascular medicine, but limited data are available for racial and ethnic minorities. The aim was to assess the burden and clinical correlates of VHD in a highly diverse area of the United States.
Cardiovascular disease is the leading cause of death in the general US population. Although the burden of valvular heart disease is increasing due to a rapidly aging population, patients can benefit from improved and more accessible imaging modalities, and novel minimally invasive treatments. However, medical knowledge and technological developments might not be generalizable to all patient backgrounds due to lack of diversity in scientific literature.
Historically, clinical trials testing new treatment modalities have lacked equitable inclusion of people coming from racial/ethnic minority groups. Similarly, epidemiological studies have focused on specific patient subsets with no direct comparisons with the other backgrounds. The Bronx county (New York, USA) is considered by the US Census as the most diverse area in the country, having the highest overwhelming concentration of non-white populations and being the only borough in all of New York City to be almost exclusively populated by non-white enclaves. These demographic characteristics make this county ideal to assess how the prevalence and the clinical correlates of valvular heart diseases might vary among diverse populations.
On this background, the objective of this registry is to assess the burden of valvular heart diseases and explore their clinical correlates in the most diverse area of the United States.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Race - American Indian or Alaska Native | Being identified as American Indian or Alaska Native | ||
| Race - Asian | Being identified as Asian | ||
| Race - Black or African-American | Being identified as Black or African-American | ||
| Race - Native Hawaiian or Other Pacific Islander | Being identified as Native Hawaiian or Other Pacific Islander | ||
| Race - White | Being identified as White | ||
| Ethnicity - Spanish/Hispanic/Latino | Being identified as Spanish/Hispanic/Latino |
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| Measure | Description | Time Frame |
|---|---|---|
| Racial/ethnical based differences in baseline characteristics and valvular heart disease | Baseline characteristics among pre-defined racial/ethnical groups will be compared for each valvular heart disease | Baseline |
| Prevalence of Valvular Heart Disease | Prevalence of each valvular heart disease will be compared among pre-defined racial/ethnical groups | Up to 10 years |
| All-cause mortality | All-cause mortality according to valvular heart disease and racial/ethnical group | Up to 10 years |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients undergoing echocardiographic assessment at Montefiore Medical Center (Bronx, NY, USA) will be included in this registry.
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| Name | Affiliation | Role |
|---|---|---|
| Azeem Latib, MD | Montefiore Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montefiore Medical Center | The Bronx | New York | 10461 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39647784 | Result | Echarte-Morales J, Scotti A, Bonnet G, Torrado J, Sturla M, Coisne A, Ludwig S, Barzallo D, Escabia C, Chandra A, Kodesh A, Aftab A, Granada JF, Ho EC, Jorde UP, Rodriguez CJ, Slipczuk L, Garcia MJ, Latib A. Racial and ethnic disparities in patients with severe tricuspid regurgitation: The Bronx-Valve registry. Int J Cardiol. 2025 Feb 15;421:132889. doi: 10.1016/j.ijcard.2024.132889. Epub 2024 Dec 6. | |
| 39817520 |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D003251 | Constriction, Pathologic |
| D005764 | Gastroesophageal Reflux |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Result |
| Scotti A, Sturla M, Echarte-Morales J, Ho EC, Millin A, Coisne A, Ludwig S, Leone PP, Rosiene J, Granada JF, Goldberg Y, Pu M, Jorde UP, Slipczuk L, Rodriguez CJ, Garcia MJ, Latib A. Burden of Valvular Heart Diseases in a Racially and Ethnically Diverse Population: The Bronx-Valve Registry. J Am Heart Assoc. 2025 Jan 21;14(2):e035378. doi: 10.1161/JAHA.124.035378. Epub 2025 Jan 16. |
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |