Valvular Heart Disease, impacting 2.5% of the population, is predominantly observed in the elderly and is on the rise. The primary conditions within this category are Aortic Stenosis and Mitral Regurgitation. These conditions are linked to considerable morbidity and mortality, presenting a formidable challenge in optimizing treatment strategies. Pathophysiology of Valvular Heart Disease remains poorly known. The aim of the present study is to identify biomarkers involved in this disease using multi-omics approaches

Inclusion Criteria:

• Patients clinically diagnosed with heart valve disease in Beijing Anzhen Hospital

Exclusion Criteria:

• Age < 18 years
• Failure to obtain medical records and ultrasound data
• Refuse follow-up

Patients with heart valve disease accorrding to Inclusion and exclusion criteria.