High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion

Efficacy of the Association of Hyaluronic Acid With High Molecular Weight, α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion in Patients at Risk

The study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, reduces the risk of miscarriage in patients at risk.

Inclusion Criteria:

• two or more previous spontaneous first trimester abortions without apparent risk factors (idiopathic polyabortion)
• Endocrinopathies
• Autoimmune diseases
• Thrombophililic or coagulation diseases

Exclusion Criteria:

• Multiple pregnancies
• Presence of genetic abnormalities of one or both partners leading to increased risk of fetal aneuploidies
• Presence of Mullerian abnormalities in the uterus
• Symptoms present at recruitment such as pelvic pain or metrorrhagia