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The aim of this study is to evaluate the clinical and radiographic success of Lesion Sterilization And Tissue Repair [ LSTR] antibiotic paste versus Zinc Oxide and Eugenol pulpectomy in the treatment of non-vital primary molars.
Primary teeth with infected root canals are a common problem, particularly in patients where the infection has reached the peri radicular tissues .
Among the pastes used in the pulp therapy of primary teeth with pulp necrosis, zinc oxide and eugenol paste has been a reference in dentistry since 1930. Endodontic treatment using zinc oxide and eugenol paste has shown satisfactory clinical and radiographic results, requires mechanical chemical preparation before filling root canals.
The main difficulties of endodontic treatment of primary molars are related to the anatomical complexity of the root canals and the long time needed to carry out the treatment. The additional difficulty involved in diagnosing root resorption is a limiting condition for determining the actual working length and instrumentation.
Other pastes have been studied, such as those containing antibiotics in their composition, thus dispensing with root canal instrumentation (such as lesion sterilization and tissue repair using triple antibiotic paste in treatment of non-vital primary molars.
Lesion sterilization and tissue repair using triple antibiotic paste has relevant clinical and radiographic success rates in treatment of non-vital primary molars.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3 MIX | Experimental | Lesion sterilization and tissue repair; preparation of modified triple antibiotic paste tap: the chemotherapeutic agents used are metronidazole tablets 500 mg (flagyl®, sanofi, egypt), ciprofloxacin tablets 500 mg (ciproxcin®,. Epico, egypt,), and doxycycline capsules 100 mg (doxymycin™ dt, el-nile pharmaceuticals, egypt). |
|
| Zinc oxide and Eugenol Pulpectomy | Active Comparator | zinc oxide and eugenol (prevestdent proâ„¢, egypt). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lesion sterilization and tissue repair | Procedure | Pulp therapy for necrotic primary molars |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Post oper3tive pain | Measured by verbal question to patient/parents | 1 month |
| Post operative pain | Measured by verbal question to patient/parents | 3 months |
| Post operative pain | Measured by verbal question to patient/parents | 6 months |
| Tenderness | Percussion test using back of a dental mirror | 1 month |
| Tenderness | Percussion test using back of a dental mirror | 3 months |
| Tenderness | Percussion test using back of a dental mirror | 6 months |
| Swelling /sinus tract or fistula | Visual examination | 1 month |
| Swelling /sinus tract or fistula | Visual examination | 3 months |
| Swelling /sinus tract or fistula | Visual examination |
| Measure | Description | Time Frame |
|---|---|---|
| Internal /External root resorption | Radiographic examination | 6 months |
| Furcation involvement /radiolucency | Radiographic examination |
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Inclusion Criteria:
Children:
Teeth:
Exclusion Criteria:
Children:
Teeth:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of oral and dental medicine | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29073902 | Background | Chen X, Liu X, Zhong J. Clinical and radiographic evaluation of pulpectomy in primary teeth: a 18-months clinical randomized controlled trial. Head Face Med. 2017 Oct 27;13(1):12. doi: 10.1186/s13005-017-0145-1. | |
| 30289365 | Background | Luengo-Fereira J, Ayala-Jimenez S, Carlos-Medrano LE, Toscano-Garcia I, Anaya-Alvarez M. Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up. J Clin Pediatr Dent. 2019;43(1):16-21. doi: 10.17796/1053-4625-43.1.4. Epub 2018 Oct 5. |
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| ID | Term |
|---|---|
| D014945 | Wound Healing |
| D015034 | Zinc Oxide |
| ID | Term |
|---|---|
| D012038 | Regeneration |
| D001686 | Biological Phenomena |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
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| zinc oxide and eugenol pulpectomy |
| Procedure |
Pulp therapy for necrotic primary molars |
|
| 6 months |
| Tooth mobility | Mobility test | 1 month |
| Tooth mobility | Mobility test | 3 months |
| Tooth mobility | Mobility test | 6 months |
| 6 months |
| 34937613 | Background | Moura J, Lima M, Nogueira N, Castro M, Lima C, Moura M, Moura L. LSTR Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for the Treatment of Primary Molars with Pulp Necrosis: A Randomized Controlled Trial. Pediatr Dent. 2021 Nov 15;43(6):435-442. |
| 27790570 | Background | Navit S, Jaiswal N, Khan SA, Malhotra S, Sharma A, Mukesh, Jabeen S, Agarwal G. Antimicrobial Efficacy of Contemporary Obturating Materials used in Primary Teeth- An In-vitro Study. J Clin Diagn Res. 2016 Sep;10(9):ZC09-ZC12. doi: 10.7860/JCDR/2016/21883.8426. Epub 2016 Sep 1. |
| 26059708 | Background | Pramila R, Muthu MS, Deepa G, Farzan JM, Rodrigues SJ. Pulpectomies in primary mandibular molars: a comparison of outcomes using three root filling materials. Int Endod J. 2016 May;49(5):413-21. doi: 10.1111/iej.12478. Epub 2015 Jul 4. |
| 33087217 | Background | Coll JA, Dhar V, Vargas K, Chen CY, Crystal YO, AlShamali S, Marghalani AA. Use of Non-Vital Pulp Therapies in Primary Teeth. Pediatr Dent. 2020 Sep 15;42(5):337-349. |
| 31206571 | Background | Zacharczuk GA, Toscano MA, Lopez GE, Ortolani AM. Evaluation of 3Mix-MP and pulpectomies in non-vital primary molars. Acta Odontol Latinoam. 2019 Apr 1;32(1):22-28. |
| 29852056 | Background | Smail-Faugeron V, Glenny AM, Courson F, Durieux P, Muller-Bolla M, Fron Chabouis H. Pulp treatment for extensive decay in primary teeth. Cochrane Database Syst Rev. 2018 May 31;5(5):CD003220. doi: 10.1002/14651858.CD003220.pub3. |
| D007287 |
| Inorganic Chemicals |
| D017967 | Zinc Compounds |