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Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low lactate | Patients with a low lactate level defined by logistic regression analysis. | ||
| High lactate | Patients with a high lactate level defined by logistic regression analysis. |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative atrial fibrillation | New-onset atrial fibrillation occurring in the immediate period after CABG | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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All consecutive adult patients undergoing isolated CABG during the study period in the Department of Cardiovascular Surgery at Basaksehir Cam Sakura City Hospital will be evaluated for possible enrollment.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zeki Temizturk, MD | Contact | 902129096000 | zekitmztrk5806@gmail.com | |
| Ahmet Can Topcu, MD | Contact | 902165001500 | ahmet.topcu@icloud.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahmet Can Topcu, MD | Başakşehir Çam & Sakura City Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Basaksehir Cam Sakura City Hospital | Recruiting | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28369234 | Background | Greenberg JW, Lancaster TS, Schuessler RB, Melby SJ. Postoperative atrial fibrillation following cardiac surgery: a persistent complication. Eur J Cardiothorac Surg. 2017 Oct 1;52(4):665-672. doi: 10.1093/ejcts/ezx039. | |
| 22813486 | Background | O'Connor E, Fraser JF. The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery. Anaesth Intensive Care. 2012 Jul;40(4):598-603. doi: 10.1177/0310057X1204000404. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 30792496 | Background | Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019 Jul;16(7):417-436. doi: 10.1038/s41569-019-0166-5. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |