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| Name | Class |
|---|---|
| Wuzhou Red Cross Hospital | OTHER |
| Zhongshan People's Hospital, Guangdong, China | OTHER |
| Hunan Cancer Hospital | OTHER |
| The Third Affiliated Hospital of Nanchang University |
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The investigators intend to compare Epstein-Barr virus antibody and Epstein-Barr virus DNA screening efficacy in first-degree relatives of nasopharyngeal carcinoma patients.
The investigators intend to test Epstein-Barr virus antibodies (Viral Capsid Antigen-immunoglobulin A， Epstein-Barr nuclear antigen 1-immunoglobulin A， early antigen-immunoglobulin A， Zta-immunoglobulin A， Rta-immunoglobulin G, Bnlf 2b) by ELISA and Epstein-Barr virus DNA by quantitative polymerase chain reaction, target sequencing and CRISPR-associated protein 12a in nasopharyngeal brushing and plasma of the same population at high-risk of nasopharyngeal carcinoma so as to determine the best method in nasopharyngeal carcinoma screening.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High risk population of nasopharyngeal carcinoma | first-degree relatives of nasopharyngeal carcinoma patients, aged 30-62 male |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EBV antibodies test | Diagnostic Test | ELISA test of VCA-IgA，EBNA1-IgA，EA-IgA， Zta-IgA ，Rta-IgG and BNLF 2b in nasopharyngeal brushing and plasma |
|
| Measure | Description | Time Frame |
|---|---|---|
| positive predictive value | the ratio of subjects truly diagnosed as nasopharyngeal carcinoma to all those who had positive test results | 3 years |
| negative predictive value | the ratio of subjects truly diagnosed as negative (do not have nasopharyngeal carcinoma) to all those who had negative test results | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| sensitivity | the percentage of subjects who test positive to those who have nasopharyngeal carcinoma | 3 years |
| specificity | the percentage of subjects who test negative to those who do not have nasopharyngeal carcinoma |
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Inclusion Criteria:
Exclusion Criteria:
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Residences in Southern China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ming-Yuan Chen, MD, PhD | Contact | 86-20-8734-3361 | chmingy@mail.sysu.edu.cn | |
| Si-Yuan Chen, MD | Contact | 86-18711150216 | chensy@sysucc.org.cn |
| Name | Affiliation | Role |
|---|---|---|
| Ming-Yuan Chen, MD, PhD | Sun Yat-sen University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| ID | Term |
|---|---|
| D000077274 | Nasopharyngeal Carcinoma |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| OTHER |
| First People's Hospital of Foshan | OTHER |
| Yuebei People's Hospital | OTHER |
| Xiangya Hospital of Central South University | OTHER |
| Changsha Central Hospital | OTHER |
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nasopharyngeal brushing and peripheral blood
| EBV DNA test | Diagnostic Test | quantitative polymerase chain reaction, CRISPR-associated protein 12a and target sequencing of EBV DNA in nasopharyngeal brushing and plasma |
|
| 3 years |
| early diagnose rate | the ratio of patients with stage I and stage II disease to all those who have nasopharyngeal carcinoma | 3 years |
| cost-effectiveness | the cost of detecting one nasopharyngeal carcinoma case | 3 years |
| D009303 |
| Nasopharyngeal Neoplasms |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |