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| Name | Class |
|---|---|
| Prince September Pte. Ltd. | UNKNOWN |
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The overall aim of this randomized controlled trial is to investigate the effects of consuming a Plant-Based Meat alternative Diet (PBMD) compared to an Animal-Based Meat Diet (ABMD) on cardiometabolic health and protein homeostasis in Chinese men and women in Singapore. This will be achieved through the following specific objectives: (1) To evaluate the effects of dietary protein source on metabolic health and glycemic control(2) To evaluate the effects of dietary protein source on risk factors of cardiovascular diseases (3) To evaluate the effects of dietary protein source on protein homeostasis and metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Animal-based meats (ABMD group) | Experimental | Participants will be instructed to substitute protein-rich foods consumed habitually with animal-based meats (ABMD group). |
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| Plant-based meat alternatives (PBMD group) | Experimental | Participants will be instructed to substitute protein-rich foods consumed habitually with Plant-based meat alternatives (PBMD group). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Animal-based meats | Dietary Supplement | Animal-based meats from beef, pork and chicken |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in metabolic health risk indicators | Glucose | Pre- and Post-intervention (Week 8) |
| Change in cardiovascular health risk indicators | Insulin | Pre- and Post-intervention (Week 8) |
| Change in metabolic health risk indicators | Fructosamine | Pre- and Post-intervention (Week 8) |
| Change in metabolic health risk indicators | 14-day continuous blood glucose monitoring (subgroup; n = 48) | Day -2 (from Week 0) to Day 12. 14 days in total |
| Change in cardiovascular health risk indicators | Total cholesterol, LDL-cholesterol, HDL-cholesterol, Triglycerides | Pre- and Post-intervention (Week 8) |
| Change in cardiovascular health risk indicators | Clinic blood pressure and ambulatory blood pressure (subgroup; n = 48) | Pre- and Post-intervention (Week 8) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in protein metabolism-related biomarkers in plasma/serum | Protein and amino acid profile | Pre- and Post-intervention (Week 8) |
| Change in protein metabolism-related biomarkers in plasma/serum |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jeyakumar C Henry, PhD | Contact | 6407 0793 | jeya_henry@sifbi.a-star.edu.sg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Nutrition Research Centre | Recruiting | Singapore | 117599 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41785660 | Derived | Fu AS, Osman F, Cameron-Smith D, Lam NYL, Mehta KA, Leow MK, Haldar S, Henry CJ, Toh DWK. Micronutrient intake and status of adults consuming plant-based meat analogues or animal-based meats as primary protein source: An 8-week randomized controlled trial. Clin Nutr. 2026 Apr;59:106610. doi: 10.1016/j.clnu.2026.106610. Epub 2026 Feb 25. | |
| 38599522 |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D000095866 | Meat Substitutes |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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| Plant-based meat alternatives | Dietary Supplement | Plant-based meat alternatives of beef, pork and chicken |
|
Urea nitrogen
| Pre- and Post-intervention (Week 8) |
| Change in protein metabolism-related biomarkers in plasma/serum | Creatinine | Pre- and Post-intervention (Week 8) |
| Change in protein metabolism-related biomarkers in plasma/serum | Albumin | Pre- and Post-intervention (Week 8) |
| Change in inflammation-related risk indicators | High sensitivity CRP | Pre- and Post-intervention (Week 8) |
| Change in anthropometric measurements | Weight | Pre- and Post-intervention (Week 8) |
| Change in anthropometric measurements | Waist and hip circumference | Pre- and Post-intervention (Week 8) |
| Change in body composition | Dual Energy X-ray absorptiometry | Pre- and Post-intervention (Week 8) |
| Toh DWK, Fu AS, Mehta KA, Lam NYL, Haldar S, Henry CJ. Plant-Based Meat Analogs and Their Effects on Cardiometabolic Health: An 8-Week Randomized Controlled Trial Comparing Plant-Based Meat Analogs With Their Corresponding Animal-Based Foods. Am J Clin Nutr. 2024 Jun;119(6):1405-1416. doi: 10.1016/j.ajcnut.2024.04.006. Epub 2024 Apr 8. |