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one of the ultimate goals in periodontology is to achieve periodontal regeneration and change the prognosis of questionable or hopeless teeth to maintainable.Bone substitutes have been actively used to reconstruct bony defects. Four categories of bone graft materials exist: Autograft, Allograft, Alloplast, and Xenograft.many researchers paid attention to human tooth as one of the intraoral donor sites due to the chemical and structural similarity between dentin and alveolar bone since both demonstrate low crystalline hydroxyl appetite (HA) with comparable calcium-to-phosphorus ratio.
Extracted tooth will be cleaned from periodontal ligaments, cementum, soft tissue attachment, caries, or restorations (if present), using a high-speed fine finishing stone and saline irrigation. The pulp chamber will be cleaned with sterile endodontic files. Subsequently, teeth will be grounded, using hand bone mill .
ADDG particles prepared by demineralization of tooth particles in 0.6N hydrochloric acid for 30 min to achieve demineralized then washed twice in saline and dried with sterile gauze. The intrabony defect will be debrided using hand and ultrasonic devices and then ADDG particles will fill the defect. Vertical or horizontal mattress sutures and additional interrupted single sutures will be performed to obtain primary closure of the interdental space. The selection of the suturing technique will be based upon the dimension of the interdental space and the thickness and height of the interdental tissues using 5-0 proline suture then follow up period at 3 months and 6 months measuring CAL which is primary outcome and radiographic bone fill , probing depth and recession which are secondary outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| autogenous demineralized dentin graft as bone substitute in treatment of intrabony defect | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| autogenous demineralized dentin graft as bone substitute in treatment of intrabony defect | Procedure | after extraction of tooth it will be grinded using hand bone mill and demineralized and placed in intrabony defect |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level gain | measured by william's periodontal probe | change from baseline at 3 month and change from baseline at 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Probing depth | measured by William's periodontal probe | change from baseline at 3 month and at 6 month |
| Radiographic bone fill | periapical radiograph using Digora system |
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Inclusion Criteria:
Motivated patient 18 years of age or order.
Teeth related criteria:
Exclusion Criteria:
Patient-related criteria:
Teeth related criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| omnia alfekky, bachelor | Contact | 1019604560 | +20 | omnia.abdlmonaem@dentistry.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| weam Elbattway, doctor | Cairo University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Recruiting | Cairo | Egypt |
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| change from baseline at 3 month and at 6 month |
| Recession | measured by William's periodontal probe | change from baseline at 3 month and at 6 month |
| ID | Term |
|---|---|
| D018786 | Bone Substitutes |
| ID | Term |
|---|---|
| D001672 | Biocompatible Materials |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
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