The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.

In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.

Inclusion Criteria:

• Patients with good systemic health and no contraindication for periodontal surgery.
• Patients who are able to maintain good oral hygiene.
• Gingival thickness for the site selected should be ≥1mm.
• Probing depth of ≥ 6mm.
• Patient has at least one hopeless teeth

Exclusion Criteria:

• Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc….).
• Medically compromised patients.
• Smokers and alcoholic abusers
• People who suffer from any systemic disease that affect the periodontium.
• Pregnant, postmenopausal women.
• People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month.
• People who use mouth washes regularly
• Participants in other clinical trials.