National Multicenter Cohort Registry Study of Rapid rEcurrences of Coronary Unexplained In-stent Restenosis

National Multicenter Cohort Registry Study of Rapid rEcurrences of Coronary Unexplained In-stent Restenosis

This project aims to establish a clinical cohort and diagnostic assessment framework by conducting a national multicenter cohort registry study. Through the collection of patients' clinical characteristics, it will achieve the registration, management, follow-up, and analysis of patients with Rapid rEcurrences of Coronary Unexplained in-stent Restenosis (RECUR).

Inclusion Criteria:

1. Age ≥ 18 years;
2. Patients meeting the diagnostic criteria for Rapid rEcurrences of Coronary Unexplained in-stent Restenosis (RECUR);
3. Patients fully informed about the trial procedures who provide written informed consent.

Exclusion Criteria:

1. Patients presenting with any of the following:

   • Other severe comorbidities (e.g., malignant tumors, heart failure) with a life expectancy <12 months;

     • Known autoimmune/rheumatic diseases including systemic lupus erythematosus, Takayasu arteritis, Behçet's disease, polyarteritis nodosa, Wegener granulomatosis (granulomatosis with polyangiitis), eosinophilic arteritis, giant cell arteritis, rheumatoid arthritis, or IgG4-related disease;

       • Variant angina (Prinzmetal's angina);

         • Coronary artery dissection;

           • Thrombophilia;

             • Stent underexpansion.

2. Presence of psychiatric disorders;

3. Known inability to complete expected study follow-up for any reason;

4. Patients deemed ineligible for enrollment by the investigator.