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Carpal tunnel syndrome is the most common peripheral entrapment neuropathy of the upper limb. Previous experiments found that ultrasound-guided median nerve hydrodissection with 5% dextrose water could ameliorate the condition of carpal tunnel syndrome. Oral administration of vitamin B 12 had been reported to reduce the discomfort from peripheral neuropathy although the level of evidence is not strong. This prospective, double-blind randomized control trial aims to compare the effects of different kinds of the injection agents on carpal tunnel syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dextrose | Active Comparator |
| |
| Vitamin B12 | Experimental |
| |
| Dextrose + Vitamin B12 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound-guided nerve hydrodissection | Procedure | Peri- median nerve injection for hydrorelease and decompression |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Boston Carpal Tunnel Syndrome Questionnaire | Measure the severity of symptoms and functional status before and after treatment | Pre-treatment, 1st, 3rd, 6th month after injection |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analog scale of pain and tingling | Measure the pain and tingling scale before treatment and after treatment. (0 is for not at all pain/tingling, and 100 is for extremely pain/tingling.) | Pre-treatment, 1st, 3rd, 6th month after injection |
| Cross-sectional area of the median nerve |
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Inclusion Criteria:
Exclusion Criteria:
Thoracic outlet syndrome
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yao-Hong Guo, MD, MSc | Contact | 886-6-2353535 | 2666 | drprps@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University | Recruiting | Tainan | Taiwan |
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| ID | Term |
|---|---|
| D002349 | Carpal Tunnel Syndrome |
| ID | Term |
|---|---|
| D020423 | Median Neuropathy |
| D020422 | Mononeuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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Using the ultrasound to measure the cross-sectional area of the median nerve before and after treatment |
| Pre-treatment, 1st, 3rd, 6th month after injection |
| Median nerve elastography | Using the ultrasound to measure the elastography of the median nerve before and after treatment | Pre-treatment, 1st, 3rd, 6th month after injection |
| Median nerve conduction velocity and amplitude | Antidromic sensory nerve conduction velocity and amplitude of the median nerve before and after treatment | Pre-treatment, 1st, 6th month after injection |
|
| D009422 | Nervous System Diseases |
| D009408 | Nerve Compression Syndromes |
| D012090 | Cumulative Trauma Disorders |
| D013180 | Sprains and Strains |
| D014947 | Wounds and Injuries |