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| Name | Class |
|---|---|
| Centro Hospitalar De São João, E.P.E. | OTHER |
| Centro de Investigação em Tecnologias e Serviços de Saúde | OTHER |
| Rede de Investigação em Saúde | OTHER |
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Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Patients aged ≥ 60 years old with symptomatic carpal tunnel syndrome submitted to surgery |
| |
| Group 2 | Patients aged ≥ 60 years old without symptomatic carpal tunnel syndrome submitted to hand surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD | Diagnostic Test | Congo red and Immunohistochemical analysis and/or Mass spectrometry analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of transthyretin amyloidosis in synovial in patients with ≥60 years old | Number of patients with transthyretin amyloidosis in synovial in relation to total number of patients submitted to hand surgery | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Association between synovial transthyretin amyloidosis with carpal tunnel syndrome | Comparison between group 1 and 2 | 24 months |
| Association between idiopathic carpal tunnel syndrome with cardiac transthyretin amyloidosis |
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Inclusion Criteria:
. Patients aged ≥ 60 years old with symptomatic idiopathic carpal tunnel syndrome or other hand surgery indications.
Exclusion Criteria:
. Diabetes mellitus, hypothyroidism, hemodialysis, rheumatoid arthritis, and other inflammatory arthropathies, multiple myeloma, gout, chondrocalcinosis, Colles fracture, space-occupying lesions, and infectious synovitis.
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Patients with ≥60 years old submitted to hand surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elisabete Martins, MD, PhD | Contact | (+351) 965913480 | ebernardes@med.up.pt | |
| Janete Santos, PhD | Contact | (+351) 225 513 600 | investigaclinica@med.up.pt |
| Name | Affiliation | Role |
|---|---|---|
| Elisabete Martins, MD, PhD | Universidade do Porto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Hospitalar Universitário São João | Recruiting | Porto | 4200-319 | Portugal |
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| ID | Term |
|---|---|
| C567782 | Amyloidosis, Hereditary, Transthyretin-Related |
| D002349 | Carpal Tunnel Syndrome |
| ID | Term |
|---|---|
| D020423 | Median Neuropathy |
| D020422 | Mononeuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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biopsy and peripheral blood
Comparison between group 1 and 2
| 24 months |
| Faculty of Medicine (FMUP) | Recruiting | Porto | 4200-319 | Portugal |
|
| D009422 | Nervous System Diseases |
| D009408 | Nerve Compression Syndromes |
| D012090 | Cumulative Trauma Disorders |
| D013180 | Sprains and Strains |
| D014947 | Wounds and Injuries |