Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome

Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome

Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.

Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.

This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.

Inclusion Criteria:

• Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years.
• Informed written and verbal consent

Exclusion Criteria:

• Operation by different indication such as

  • Fracture
  • Ganglion
  • Tumors
  • Osteophytes
  • Rheumatoid Arthritis
  • Persistent medial artery
  • Metabolic causes

• Alcoholism

• Hyperthyroidism

• Myxedema

  • Hereditary Cardiac Amyloidosis
  • Known WT ATTR
  • AL Amyloidosis
  • Myelomatosis
  • MGUS and Morbus Waldenström