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To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acitretin | Active Comparator | Patients will Receive Acitretin (0.25-1 mg /kg/day )for 3months . |
|
| Narrowband ultraviolet B | Active Comparator | Patients will receive Narrowband UVB( 3session /week ) for 3months. |
|
| Combination of Narrowband ultraviolet B and Acitretin | Active Comparator | Patients will receive Acitretin (0.25-1 mg /kg/day ) and Narrowband UVB( 3session /week ) for 3 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acitretin 25Mg Cap | Drug | Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum Neopterin in psoriasis | Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay). | 3 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment of psoriasis | Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB, Acitretin and combination of both modalities. | 3 Months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Valley University | Qina | Egypt |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D017255 | Acitretin |
| D002214 | Capsules |
| ID | Term |
|---|---|
| D012176 | Retinoids |
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 |
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| Narrowband ultraviolet B | Radiation | Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months |
|
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| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013729 | Terpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |