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The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum TWEAK level in psoriatic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Narrowband ultraviolet B | Active Comparator | Patients will receive 8 sessions of NB-UVB per month for 3 successive months |
|
| Methotrexate group | Active Comparator | Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months |
|
| healthy individuals as control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Narrowband ultraviolet B | Radiation | Patients will receive 8 sessions of NB-UVB per month for 3 successive months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum TWEAK in psoriasis | Measurement of tumor necrosis factor weak inducer of apoptosis (TWEAK) "pg/ml"; in psoriatic patients before and after treatment with NB-UVB versus MTX in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay). | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment of psoriasis | Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB in comparison with MTX. Patients will be photographed at baseline and after 3 months of regular treatment by using high resolution digital camera canon EOS 1300D 18 megapixels (made in taiwan), photography will be done in standard light and distance. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Moustafa A El Taieb, Professor | Faculty of medicine aswan university | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University - Faculty of Medicine | Aswān | Aswan Governorate | 81528 | Egypt |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D008727 | Methotrexate |
| ID | Term |
|---|---|
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| Methotrexate | Drug | Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months |
|
|
| 3 months |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |